Dr. Simon Duffy, Ph.D.Instructor
Columbia College |
Teaching Experience
Research Experience and Interests
My doctoral research at the University of Victoria focused on baculovirus genomics and gene expression. I sequenced the genome of the Balsam Fir Sawfly baculovirus.
Duffy, S. P., Young, A. M., Morin, B., Lucarotti, C. J., Koop, B. F., & Levin, D. B. (2006). Sequence analysis and organization of the Neodiprion abietis nucleopolyhedrovirus genome. Journal of virology, 80(14), 6952-6963. Duffy, S. P., Becker, E. M., Whittome, B. H., Lucarotti, C. J., & Levin, D. B. (2007). In vivo replication kinetics and transcription patterns of the nucleopolyhedrovirus (NeabNPV) of the balsam fir sawfly, Neodiprion abietis.Journal of general virology, 88(7), 1945-1951. |
My postdoctoral work at the Toronto Hospital for Sick Children and the University of Toronto focused on the association between viral receptors and human congenital disease.
Rey, M. A., Duffy, S. P., Brown, J. K., Kennedy, J. A., Dick, J. E., Dror, Y., & Tailor, C. S. (2008). Enhanced alternative splicing of the FLVCR1 gene in Diamond Blackfan anemia disrupts FLVCR1 expression and function that are critical for erythropoiesis. Haematologica, 93(11), 1617-1626. Shalev, Z., Duffy, S. P., Adema, K. W., Prasad, R., Hussain, N., Willett, B. J., & Tailor, C. S. (2009). Identification of a feline leukemia virus variant that can use THTR1, FLVCR1, and FLVCR2 for infection. Journal of virology, 83(13), 6706-6716. Jandu, N., Ho, N. K., Donato, K. A., Karmali, M. A., Mascarenhas, M., Duffy, S. P., ... & Sherman, P. M. (2009). Enterohemorrhagic Escherichia coli O157∶ H7 Gene Expression Profiling in Response to Growth in the Presence of Host Epithelia. PLoS One, 4(3), e4889. Duffy, S. P., Shing, J., Saraon, P., Berger, L. C., Eiden, M. V., Wilde, A., & Tailor, C. S. (2010). The Fowler syndrome-associated protein FLVCR2 is an importer of heme. Molecular and cellular biology, 30(22), 5318-5324. Duffy, S., & Cochrane, A. Analysis of HIV-1 RNA Splicing. Alternative pre-mRNA Splicing: Theory and Protocols, 438-448. |
In conjunction with bioengineers at UBC, I have been involved in the development of innovative technologies for the diagnosis, prognosis and study of blood disorders and cancer.
Jin, C., McFaul, S. M., Duffy, S. P., Deng, X., Tavassoli, P., Black, P. C., & Ma, H. (2014). Technologies for label-free separation of circulating tumor cells: from historical foundations to recent developments. Lab on a Chip, 14(1), 32-44. Park, S., Ang, R. R., Duffy, S. P., Bazov, J., Chi, K. N., Black, P. C., & Ma, H. (2014). Morphological differences between circulating tumor cells from prostate cancer patients and cultured prostate cancer cells. PloS one, 9(1), e85264. Matthews, K., Myrand-Lapierre, M. E., Ang, R. R., Duffy, S. P., Scott, M. D., & Ma, H. (2015). Microfluidic deformability analysis of the red cell storage lesion. Journal of biomechanics, 48(15), 4065-4072. Todenhöfer, T., Park, E., Abdi, H., Li, A., Ross, R., Deng, X., ... & Black, P. (2015). MP1-07 ENRICHMENT OF CIRCULATING TUMOR CELLS IN PATIENTS WITH LOCALIZED PROSTATE CANCER USING A MICROFLUIDIC DEVICE. The Journal of Urology, 193(4), e3. Deng, X., Duffy, S. P., Myrand-Lapierre, M. E., Matthews, K., Santoso, A. T., Du, Y. L., ... & Ma, H. (2015). Reduced deformability of parasitized red blood cells as a biomarker for anti-malarial drug efficacy. Malaria journal, 14(1), 1-9. Guo, Q., Duffy, S. P., Matthews, K., Deng, X., Santoso, A. T., Islamzada, E., & Ma, H. (2016). Deformability based sorting of red blood cells improves diagnostic sensitivity for malaria caused by Plasmodium falciparum. Lab on a Chip. Park, E. S., Jin, C., Guo, Q., Ang, R. R., Duffy, S. P., Matthews, K., . . . Ma, H. (2016). Continuous Flow Deformability-Based Separation of Circulating Tumor Cells Using Microfluidic Ratchets. Small, 12(14), 1909-1919. doi:10.1002/smll.201503639 |